*Applications will be reviewed on a rolling-basis.
Two research opportunities are currently available with the Division of Bacterial, Parasitic, and Allergenic Products (DBPAP), in the Office of Vaccines Research and Review (OVRR), at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) located in Silver Spring, Maryland.
The ORISE Research Participation Program at the U.S. Food and Drug Administration is an educational and training program designed to provide college students, recent graduates, and university faculty opportunities to connect with the unique resources of the FDA. With the support of an assigned mentor, participants have authentic hands-on research experience and allows them access to unique research opportunities, top scientists and engineers, and state-of the art facilities and equipment. The Center for Biologics Evaluation and Research (CBER) is one Center within the Food and Drug Administration, an Agency within the United States Government’s Department of Health and Human Services. CBER’s mission is to protect and enhance the public health through the regulation of biological and related products including blood, vaccines, allergenics, tissues, and cellular and gene therapies.
Both projects focus on the innate response to viral infection by respiratory epithelial cells and the links between viral respiratory infections and asthma. Each participant will be performing in vitro cell biology and gene transcription experiments, using standard immunobiochemical techniques to analyze signaling pathways, manipulating gene expression with siRNA and lentiviral constructs, and performing confocal microscopy and time lapse imaging for viral inhibition mechanistic studies.
The first project, “Local control of respiratory syncytial virus (RSV) by respiratory epithelial cells,” compares the innate immune response of two respiratory epithelial cell lines, one of which is permissive to infection by respiratory syncytial virus, and one that resists infection. The overall goals of the project are to define critical for local control of RSV infection of this virus. The candidate is referred to Hillyer et al. J Virol 2018 (PMID: 29769339).
The second project, “Impact of Allergens on the Innate Immune Response in Lung Epithelial Cells,” investigates how house dust mite (HDM) allergens impact innate immune responses to human rhinovirus (HRV). We have shown that HDM proteins impair the antiviral response to HRV in respiratory cell lines. The goals of this project are to and identify responsible HDM protein(s) define the mechanism of inhibition.
Anticipated Appointment Start Date: July 2021
This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the Silver Spring, Maryland, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.